Titus Lucretius Carus - De Rerum Natura (On the Nature of Things)
Biblioteca Malatestiana in Cesena. Unfortunately I don't know how old this copy is.

Neume initial
Biblioteca Malatestiana, Cesena.

Life of Mary by Ugolino di Prete Ilario
Life of Mary by Ugolino di Prete Ilario (1370), detail. Orvieto cathedral.

Life of Mary by Ugolino di Prete Ilario
Life of Mary by Ugolino di Prete Ilario (1370), detail. Orvieto cathedral.

Madonna of Senigallia
Madonna of Senigallia (1474) by Piero della Francesca. Palazzo Ducale, Urbino.

Flagellation of Christ
Flagellation of Christ (1460) by Piero della Francesca. Palazzo Ducale, Urbino.

Flagellation of Christ
Flagellation of Christ (1460) by Piero della Francesca. Palazzo Ducale, Urbino.

Institution of Eucharist
Institution of Eucharist (1473-1476) by Joos Van Wassenhove (Giusto di Gand) and Corpus Domini predella (1467-1468) by Paolo Uccello. Palazzo Ducale, Urbino.